I'd say that the Bills would have stopped that 4th down anyway, but they probably would received a 15 yard penalty for hurting Mariota's feelings while doing so.
Now just imagine if the NFL was like the other leagues and had far more games. Just think of the massive number of horrible calls we'd be exposed to. I know we get a ton of ref complaints out of hockey games, but my god, the NFL is on a whole different level.
But hey, it would give them a chance to squeeze in a few more commercial breaks. It's win/win!