Doesn't matter, it's all cyclical. Strike while the iron is hot, I say.
Look at PIT. Their all-world defenseman missed the entire post-season, and still, they reached the top of the mountain with cast-offs like Shultz, Daley, Cole, Streit, Hainsey, Ruhwedel, etc...
In BUF's case, they just need 1 or 2 quality bottom pairing guys to replace Gorges and Franson... they don't need top 10 picks.